A pathologist has told the Alesha MacPhail murder trial that the six-year-old died after significant pressure was applied to her face and neck.
John Williams also told the court that Alesha had 117 injuries, although some could have been caused by vegetation.
He agreed that some injuries were consistent with smothering.
A 16-year old boy denies abducting, raping and murdering the schoolgirl on the Isle of Bute.
He cannot be named due to his age.
It is alleged that Alesha was taken from the home her grandparents shared with her father.
Dr Williams was one of the pathologists who carried out the post-mortem examination on her body after she was found in woodland at a disused hotel on 2 July last year.
He told the High Court in Glasgow the injuries to Alesha’s neck and face were consistent with being gripped, and those to her nose and mouth were consistent with smothering.
He added it was also possible her windpipe was pushed shut.
Dr Williams also said Alesha had “catastrophic” genital injuries, more severe than he had ever seen before.
And he said Alesha’s feet appeared to be uninjured which he agreed would be consistent with her being carried to the area.
The 16-year-old accused has also been charged with attempting to hide evidence.
He has claimed it was Toni McLachlan, the partner of Alesha’s father, who killed her.
During her evidence to the court on Wednesday, Ms McLachlan insisted she had nothing to do with Alesha’s death, telling jurors: “I loved her to pieces.”